That's a bad idea of the plugin developer: It would allow a virus to replace the plugin dll (wlx) and then run with full admin rights when the user launches Total Commander with them.Most likely you do not have access to the IrfanView folder. The readme says that when installing IV in system folders, you need to open access to it.
Instead, the plugin should implement the function ListSetDefaultParams, which tells the plugin via DefaultIniName field where it should store its settings. This is the same directory where Total Commander stores the wincmd.ini. Just remove the ini nanem from DefaultIniName and append your own.