Total Commander

After a brief experimenting with trial version of TC I found "Syncronise Dirs" tool is probably the best available tool of sorts on Windows but the fact that it can be only ran manually is a bummer.

May I suggest releasing it as a separate utility able to run in background and run on a schedule?

The possible scenario of use is: I want backup my home directory to OneDrive or mounted NFS/CIFS share every X hours and obvious choice for this task rsync does not work very well on NTFS.

The idea is that there can be predefined "profiles" for synchronization tasks where one can specify source and destination and copying rules and how often they can be ran, i.e. hourly, daily, etc.

Thank you, regardless of whether you decide doing it or not.

For such automations I use robocopy. You can configure it very finely. The Tc is more suitable for special tasks that cannot be automated, where you have to take a look at it.

Try also SyncToy. It's pretty old (2009), but still works even on Windows 11.

You can automate the compare step, but not the copy step. Example:
totalcmd64.exe /S=S:=name_of_stored_settings