Ok, there are different tastes and working behaviours but, hell, standardisation never hurts!
So, here is a small example of settings that I cannot live without them (that's just a tiny sample to get things started):
For wincmd.ini:
* SortUpper=2 - For the famous natural sorting. Bringing computers closer to human ways of thinking!
* ReverseHistory=1 (new) - I always liked the idea of last in first out!

* RenameSelOnlyName=1 (new) - Well 98% of the cases I'm renaming just the file name after all
* StartupScreen=0 - Improve start up time and since I'm a registered user I don't need to be reminded about that any way!

For wcx_ftp.ini:
* FtpInBackground=1 - So that you can keep on using TC while downloading. I have the setting to only have one TC instance ON so I need this feature badly!

* TcpKeepAlive=1 (new) - To avoid connection breaking on certain firewalls/routers
PS: Bear in mind that what I want to achieve with this thread it's a collection of widely-accepted options that will fit the majority of user needs who can save the info within a text file and use easily in the future by copy-pasting the settings. In addition I'm talking about manual settings and not changes to ini files sourced from changes in the configuration section of TC.